Actions

The scientific work of the CROME-LIFE project is organised in the following six actions:

Action B.1 is divided into two inter-related tasks, focusing respectively on the current knowledge and methodology and on methodological framework development.

Action B.2 encompasses three tasks, focusing respectively on the collection, quality assessment and storing of datasets to be used as main input in the CROME-LIFE methodology.

Action B.3 encompasses two tasks dealing with the design and execution of the environmental and human biomonitoring campaigns.

Action B.4 is divided into four inter-related tasks, focusing respectively on the application of multimedia modeling to assess environmental concentrations of the selected chemicals in the different environmental media starting from environmental monitoring values, on the application of models for exposure assessment for total populations and for targeted population sub-groups and on the development of a lifetime generic PBTK model both in the forward mode to estimate the concentration of chemicals in the target tissues and in backward mode (reverse dosimetry) to reconstruct exposure estimates from biomonitoring data.

The Action B.5 is split into two main tasks: the first comprises the forward use of physiology-based toxicokinetic models to assess internal exposure to associated to external exposure results gathered from Action B.4 as well as their backward use to reconstruct the exposure patterns of the local population to the selected chemicals based on biomonitoring data; the second regards the use of exposure and epidemiological data with PBTK models and HBM data through the application of advanced statistical tools to interpret the biomonitoring data collected in Actions B.2 or measured in Action B.3 towards a more precise assessment of the health impact associable to environmental burden in the areas of interest to the project.

The Action B.6 has only one task focusing on the development of guidelines for the reproducibility and generalized application of the methodology proposed.

Task Start month End month Leader Partners involved
1.1 1 3 AUTH CSIC, ISS, JSI
1.2 3 6 AUTH CSIC, ISS, JSI
2.1 3 9 CSIC AUTH, ISS, JSI
2.2 6 12 JSI AUTH
2.3 6 12 AUTH
3.1 12 15 JSI AUTH, CSIC, ISS
3.2 12 24 JSI AUTH, CSIC, ISS
4.1 18 24 AUTH CSIC
4.2 24 30 CSIC AUTH, ISS, JSI
4.3 12 24 AUTH
4.4 24 33 AUTH
5.1 24 30 ISS AUTH, JSI
5.2 24 33 ISS AUTH, CSIC, JSI
6.1 30 39 ISS AUTH, CSIC, JSI
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